Early-life external exposome in children 2-5 years old in Colombia.

Exposome studies are advancing in high-income countries to understand how multiple environmental exposures impact health. However, there is a significant research gap in low- and middle-income and tropical countries. We aimed to describe the spatiotemporal variation of the external exposome, its correlation structure between and within exposure groups, and its dimensionality. A one-year follow-up cohort study of 506 children under 5 in two cities in Colombia was conducted to evaluate asthma, acute respiratory infections, and DNA damage. We examined 48 environmental exposures during pregnancy and 168 during childhood in eight exposure groups, including atmospheric pollutants, natural spaces, meteorology, built environment, traffic, indoor exposure, and socioeconomic capital. The exposome was estimated using geographic information systems, remote sensing, spatiotemporal modeling, and questionnaires. The median age of children at study entry was 3.7 years (interquartile range: 2.9-4.3). Air pollution and natural spaces exposure decreased from pregnancy to childhood, while socioeconomic capital increased. The highest median correlations within exposure groups were observed in meteorology (r = 0.85), traffic (r = 0.83), and atmospheric pollutants (r = 0.64). Important correlations between variables from different exposure groups were found, such as atmospheric pollutants and meteorology (r = 0.76), natural spaces (r = -0.34), and the built environment (r = 0.53). Twenty principal components explained 70%, and 57 explained 95% of the total variance in the childhood exposome. Our findings show that there is an important spatiotemporal variation in the exposome of children under 5. This is the first characterization of the external exposome in urban areas of Latin America and highlights its complexity, but also the need to better characterize and understand the exposome in order to optimize its analysis and applications in local interventions aimed at improving the health conditions and well-being of the child population and contributing to environmental health decision-making.

Characterization of the external exposome and its contribution to the clinical respiratory and early biological effects in children: The PROMESA cohort study protocol.

BACKGROUND: Air pollution contains a mixture of different pollutants from multiple sources. However, the interaction of these pollutants with other environmental exposures, as well as their harmful effects on children under five in tropical countries, is not well known. OBJECTIVE: This study aims to characterize the external exposome (ambient and indoor exposures) and its contribution to clinical respiratory and early biological effects in children. MATERIALS AND METHODS: A cohort study will be conducted on children under five (n = 500) with a one-year follow-up. Enrolled children will be followed monthly (phone call) and at months 6 and 12 (in person) post-enrolment with upper and lower Acute Respiratory Infections (ARI) examinations, asthma development, asthma control, and genotoxic damage. The asthma diagnosis will be pediatric pulmonologist-based and a standardized protocol will be used. Exposure, effect, and susceptibility biomarkers will be measured on buccal cells samples. For environmental exposures PM2.5 will be sampled, and questionnaires, geographic information, dispersion models and Land Use Regression models for PM2.5 and NO2 will be used. Different statistical methods that include Bayesian and machine learning techniques will be used for the ambient and indoor exposures-and outcomes. This study was approved by the ethics committee at Universidad Pontificia Bolivariana. EXPECTED STUDY OUTCOMES/FINDINGS: To estimate i) The toxic effect of particulate matter transcending the approach based on pollutant concentration levels; ii) The risk of developing an upper and lower ARI, based on different exposure windows; iii) A baseline of early biological damage in children under five, and describe its progression after a one-year follow-up; and iv) How physical and chemical PM2.5 characteristics influence toxicity and children's health.

Commuter's personal exposure to air pollutants after the implementation of a cable car for public transport: Results of the natural experiment TrUST.

Commuters in urban settlements are frequently exposed to high concentrations of air pollutants due to their proximity to mobile sources, making exposure to traffic-related air pollutants an important public health issue. Recent trends in urban transport towards zero- and low-tailpipe emission alternatives will likely result in decreased exposure to air pollutants. The TrUST (Urban transformations and health) study offers a unique opportunity to understand the impacts of a new cable car (TransMiCable) in underserved communities within Bogotá, Colombia. The aims of this study are to assess the personal exposure to fine particulate matter (PM2.5), equivalent Black Carbon (eBC), and Carbon Monoxide (CO) in transport micro-environments and to estimate the inhaled dose per trip during mandatory multimodal trips before and after the implementation of the TransMiCable. We collected personal exposure data for Bus-Rapid-Transit (BRT) feeder buses, regular buses, informal transport, pedestrians, and TransMiCable. TransMiCable showed lower exposure concentration compared to BRT feeder and regular buses (PM2.5: 23.6 vs. 87.0 µg m-3 (P ≤ 0.001) and eBC: 5.2 vs. 28.2 µg m-3 (P ≤ 0.001), respectively). The mean concentration of PM2.5 and eBC inside the TransMiCable cabins were 62 % and 82 % lower than the mean concentrations in buses. Furthermore, using a Monte Carlo simulation model, we found that including the TransMiCable as a feeder is related to a 54.4 µg/trip reduction in PM2.5 inhaled dose and 35.8 µg/trip in eBC per trip. Those changes represent a 27 % and 34 % reduction in an inhaled dose per trip, respectively. Our results show that PM2.5, eBC, and CO inhaled dose for TransMiCable users is reduced due to lower exposure concentration inside its cabins and shorter travel time. The implementation of a cable car in Bogotá is likely to reduce air pollution exposure in transport micro-environments used by vulnerable populations living in semi-informal settlements.

Toward Cleaner Transport Alternatives: Reduction in Exposure to Air Pollutants in a Mass Public Transport.

Commuters are often exposed to higher concentrations of air pollutants due to its proximity to mobile sources. Despite recent trends in urban transport toward zero- and low-tailpipe emission alternatives, the assessments of the impact of these transformations on commuter exposure are limited by the low frequency of such studies. In this work, we use a unique data set of personal exposure concentration measurements collected over the span of 5 years to analyze changes due to the introduction of a new fleet for Bogotá's Bus Rapid Transit System. In that system, over a thousand Euro-II and -III diesel-powered buses were replaced with Euro-VI compressed natural gas and filter-equipped Euro-V diesel buses. We measured personal exposure concentrations of equivalent black carbon (eBC), fine particulate (PM2.5), and ultra fine particles (UFP) during and after the retirement of old buses and the introduction of new ones. Observations collected prior to the fleet renewal were used as baseline and later compared to data collected over two follow-up campaigns in 2019 and 2020. Significant reductions in the concentration of PM2.5 and eBC were observed during the 2019 campaign, with a 48% decrease for mean in-bus eBC (89.9 to 46.4 µg m-3) and PM2.5 (180.7 to 95.4 µg m-3) concentrations. Further reductions were observed during the 2020 follow-up, when the fleet renovation was completed, with mean in-bus eBC decreasing to 17.7 µg m-3 and PM2.5 to 42.3 µg m-3. These observations imply nearly a 5-fold reduction in eBC exposure and a 4-fold decrease in PM2.5. There was a much smaller reduction of in-bus UFP concentration between 2019 and 2020, indicating a persistent presence of high particle number concentrations in the near-road environment despite the fleet renovation process. In-bus UFP concentrations ranged between 65 000 and 104 500 cm-3 during the follow-up campaigns. The results in this work illustrate the immediate benefits of reducing personal exposure through the adoption of vehicles with more stringent emission standards.

Assessment of Personal Exposure to Particulate Air Pollution in Different Microenvironments and Traveling by Several Modes of Transportation in Bogotá, Colombia: Protocol for a Mixed Methods Study (ITHACA).

BACKGROUND: Air pollution in most countries exceeds the levels recommended by the World Health Organization, causing up to one-third of deaths due to noncommunicable diseases. Fine particulate matter (PM2.5) and black carbon (BC) from mobile sources are the main contaminants. OBJECTIVE: The aim of this study is to assess the relationship of exposure to air pollutants (PM2.5 and BC) in microenvironments according to respiratory health and physical activity in users traveling by different types of transportation in Bogotá, Colombia. METHODS: A mixed methods study based on a convergent parallel design will be performed with workers and students. The sample will include 350 healthy transport users traveling by different urban transportation modes in three main routes in Bogotá. The study is broken down into two components: (1) a descriptive qualitative component focused on assessing the individual perception of air pollution using semistructured interviews; and (2) a cross-sectional study measuring the individual exposure to PM2.5 and BC using portable instruments (DustTrak and microAeth, respectively), pulmonary function by spirometry, and physical activity with accelerometry. The analysis will include concurrent triangulation and logistic regression. RESULTS: The findings will be useful for the conception, design, and decision-making process in the sectors of health and mobility from public, academy, and private perspectives. This study includes personal measurements of PM2.5 and BC during typical trips in the city to assess the exposure to these contaminants in the major roadways in real time. The study further compares the performance of two different lung tests to identify possible short-term respiratory effects. As a limitation, the protocol will include participants from different institutions in the city, which are not necessarily representative of all healthy populations in Bogotá. In this sense, it is not possible to draw causation conclusions. Moreover, a convergent parallel design could be especially problematic concerning integration because such a design often lacks a clear plan for making a connection between the two sets of results, which may not be well connected. Nevertheless, this study adopts a procedure for how to integrate qualitative and quantitative data in the interpretation of the results and a multilevel regression. The time that participants must live in the city will be considered; this will be controlled in the stratified analysis. Another limitation is the wide age range and working status of the participants. Regional pollution levels and episodes (PM2.5) will be handled as confounding variables. The study is currently in the enrollment phase of the participants. Measurements have been made on 300 participants. Pandemic conditions affected the study schedule; however, the results are likely to be obtained by late 2022. CONCLUSIONS: This study investigates the exposure to air pollutants in microenvironments in Bogotá, Colombia. To our knowledge, this is the first mixed methods study focusing on PM2.5, BC, and respiratory health effects in a city over 2 meters above sea level. This study will provide an integration of air pollution exposure variables and respiratory health effects in different microenvironments. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/25690.

Estimating the air quality and health impacts of biomass burning in northern South America using a chemical transport model.

Biomass burning (BB) emissions significantly deteriorate air quality in many regions worldwide, impact human health and perturbing Earth's radiation budget and climate. South America is one of largest contributors to BB emissions globally. After Amazonia, BB emissions from open and agricultural fires of Northern South America (NSA) are the most significant. Recent evidence shows a strong correlation between fire counts in NSA and Brown Carbon in some Colombian cities, suggesting a substantial seasonal contribution of regional BB sources to air pollution levels in the densely populated areas of NSA. In this work we use the atmospheric regional chemical transport model WRF-Chem to assess the contribution of open BB events to pollutant concentration and to estimate potential health impacts associated with wildfire events in NSA. Three nested domains are used to simulate atmospheric composition in the Northern part of South America and the Caribbean. Simulations included biogenic and anthropogenic emissions from a global emission inventory merged with local emissions for the city of Bogotá. Two modelling scenarios were considered, a base case without BB emissions (NO_FIRE) and a sensitivity scenario with BB emissions. Simulations were carried out for periods of strong BB activity in NSA. In the NO_FIRE scenario, aerosol concentrations are unrealistically low. When BB emissions are is included background PM2.5 concentrations increase 80%. The increment in aerosol concentrations is mainly driven by Secondary Organic Aerosols. In the case of Bogotá, the most densely populated city in the domain, monthly mean increase in PM2.5 is 3.3 µg m-3 and 4.3 ppb for O3. Modeled meteorological and air pollution fields are in better agreement with observations when high spatial resolution (3 × 3 km) is used in the simulations. The total estimated short-term all-cause mortality associated to BB during February in the region is 171 cases, 88 PM2.5-related and 83 O3-related mortality.